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By Frank Miller

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300 is a historically-inspired 1998 comedian publication restricted sequence written and illustrated via Frank Miller with painted shades by way of Lynn Varley.

The comedian is a fictional retelling of the conflict of Thermopylae and the occasions best as much as it from the point of view of Leonidas of Sparta. three hundred used to be relatively encouraged by way of the 1962 movie The three hundred Spartans, a film that Miller watched as a tender boy. The paintings was once tailored in 2007 to a movie of an analogous name.

Every web page of the comedian used to be illustrated as a double-page unfold. whilst the sequence was once accrued into hardcover shape, the person pages have been two times as huge as an ordinary comedian. Miller's paintings kind for this venture used to be just like his Sin urban paintings, even supposing the addition of constant colour is an seen difference.

300 was once before everything released as a per thirty days five-issue comedian publication constrained sequence by means of darkish Horse Comics, the 1st factor released in might 1998. the problems have been titled Honor, accountability, Glory, wrestle and Victory. The sequence received 3 Eisner Awards in 1999: "Best restricted Series", "Best Writer/Artist" for Frank Miller and "Best Colorist" for Lynn Varley. The paintings used to be accrued as a hardcover quantity in 1999.

The approval for the movie has boosted revenues of the alternate paperback variation. The tenth printing had an introduced print run of 40,000 copies, with an eleventh printing to stick with. this is often as well as the 88,000 copies already bought because the preliminary quantity was once published in 1999.

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Significant risk factors for heart-related complications include age > 70 years, current or previous angina, history of myocardial infarction (MI), Q wave on ECG, and congestive heart failure (CHF). Patients with none of these comorbidities are at a low risk for cardiac complications. Patients with ≥ 3 are at high risk, and all others are at a moderate risk. Another risk assessment tool is the Goldman index, which uses clinical, ECG, and laboratory data to determine preoperative cardiac risk (for noncardiac surgery).

His cortisol level increases by 7 μg/dL. Based on this failed stimulation test, administer hydrocortisone 100 mg ADRENAL INSUFFICIENCY One of the differential diagnoses for a hypotensive patient with a history of chronic steroid therapy. Patients undergoing moderate or major surgery with documented or presumed hypothalamic-pituitary-adrenal axis suppression should receive stress dose steroids. Always rule out other common causes of hypotension (eg, hypovolemia, anemia, sepsis). See Chapter 12 for additional details.

May be open, blinded, or double-blinded. Major advantage is that both known and unknown confounders are evenly distributed between two groups. ■ ■ SU RG ICAL PRI NC I PLES ■ ■ ■ A new endoscopic intervention has been shown to decrease the risk of postoperative DVT from 1/10 to 1/20. What is the number needed to treat? Divide 100 by the absolute risk reduction: 100 / (10% − 5%) = 100/5 = 20 patients must be treated for one to have a benefit. EPIDEMIOLOGIC TERMS Relevant ideas are summarized in Table 2-9.

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